An Epstein-Barr Virus Positive Lymphoepithelioma-Like Cholangiocarcinoma in A Young Woman with Chronic Hepatitis B Treated through Microwave Ablation: A Case Report and Literature Review

doi:10.37015/AUDT.2023.220049

Abstract

Abstract:

Lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare subtype of carcinoma that is poorly reported. We report a case of LELCC in a 28-year-old female with chronic hepatitis B. She underwent secondary microwave ablation for residual tumor following the failure of radiofrequency ablation (RFA). Image fusion technology was used to accurately diagnose that the second lesion represented residual tumor. This case is the second successful application of microwave ablation in the treatment of LELCC. We first reviewed the ultrasonographic features of LELCC. We report this case to improve our understanding of this disease and provide evidence for its clinical treatment.

Key words: Lymphoepithelioma-like cholangiocarcinoma; Microwave ablation; Ultrasound

Lanxia Zhang, MM, Qingjing Zeng, MD, Guanghui Guo, MM, Xuqi He, MM, Kai Li, MD. An Epstein-Barr Virus Positive Lymphoepithelioma-Like Cholangiocarcinoma in A Young Woman with Chronic Hepatitis B Treated through Microwave Ablation: A Case Report and Literature Review. Advanced Ultrasound in Diagnosis and Therapy, 2023, 7(4): 405-408.

Figures/Tables 4

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Table 1

References 18

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	Reference	Age	Sex	EBV	HBV	HCV	Size (cm)	Ultrasound	CEUS
1	Our	28	F	P	P	N	1.2	Hypoechoic lesion with no obvious blood flow signals	Hyperenhancement in the arterial phase, hypoenhancement in the portal phase and delayed phase
2	Chen et al. [14]	67	F	P	N	P	5	Mixed echoic	Unknown
3	Chen et al. [14]	41	M	N	P	N	3	Hypoechoic	Unknown
4	Jeng et al. [15]	50	F	P	P	N	4	Hypoechoic	Unknown
5	Liao et al. [2]	35	F	P	P	N	1.7	Hypoechoic	Unknown
6	Liang et al. [16]	64	M	P	P	N	2.3	Hypoechoic nodule with no blood flow signals	Unknown
7	Liang et al. [16]	40	M	P	P	N	3.5	Hypoechoic nodule with no blood flow signals	Hyperenhancement in the arterial phase, hypoenhancement and rim-like slight hyperenhancement in the portal phase and delayed phase
8	Nogami et al. [5]	27	F	P	P	N	1	Hypoechoic	Hyperenhancement in the arterial phase, perfusion defect in the Kupffer phase
9	Zhang et al. [17]	36	F	P	N	N	11.5	Hypoechoic	Unknown
10	Li et al. [6]	51	M	N	N	P	5.1	Hypoechoic	Hyperenhancement in the arterial phase, hypoenhancement in the portal and delay phases
11	Chen et al. [18]	74	F	P	N	N	4.3	Hypoechoic and aberrant subcapsular vascular patterns	Enhancement in the arterial phase, hypoenhancement in the portal and delay phases