Advanced Ultrasound in Diagnosis and Therapy ›› 2024, Vol. 8 ›› Issue (4): 231-241.doi: 10.37015/AUDT.2024.240053
• Review Articles • Previous Articles Next Articles
Shama Shitia, Xie Xinxina, Wu Ruiqia, He Pinga, Li Xiaodab, Chen Qingfengc, Liang Xiaolonga,*(
)
Received:2024-10-07
Accepted:2024-10-30
Online:2024-12-30
Published:2024-11-12
Contact:
Liang Xiaolong,
E-mail:xiaolong_liang@bjmu.edu.cn
Shama Shiti, Xie Xinxin, Wu Ruiqi, He Ping, Li Xiaoda, Chen Qingfeng, Liang Xiaolong. Advancements in BaTiO3-Based Ultrasound‐Triggered Piezoelectric Catalysis for Tumor Therapy. Advanced Ultrasound in Diagnosis and Therapy, 2024, 8(4): 231-241.
Figure 2
(A) Schematic representation of tumor therapy initiated by the piezoelectric effect; (B) Timeline of O2 evolution from P-BTO nanoparticles; (C) Fluorescence microscopy images of DCFH-DA in 4T1 cells following various treatments; (D) Changes in tumor volume in mice bearing 4T1 tumors; (E) Relative levels of HIF-α following different treatments. (Reprinted with permission from[22]. Copyright 2021, American Chemical Society.)"
Figure 3
(A) Schematic illustration of efficient tumor chemotherapy utilizing US-triggered piezoelectric catalysis combined with a nanomedicine approach; (B) Fluorescence intensity of SOSG triggered by ultrasound across various samples; (C) NO release profiles of different experimental groups upon ultrasound activation; (D) Release behavior of CPT from various samples under ultrasound stimulation; (E) Quantitative analysis of calcein-AM/PI fluorescence images from Panc02 tumor cells subjected to different treatments; (F) Tumor growth curves for mice following various treatment regimens. (Reprinted with permission from [27]. Copyright 2023, American Chemical Society.)"
Figure 4
(A) Schematic of the piezoelectric effect to enhance tumor NO gas therapy; (B) US-triggered O2 generation at different power intensities; (C) US-triggered 1O2 generation at different power intensities; (D) US-triggered NO generation at different power intensities; (E) Quantitative analysis of HIF-1α protein levels in 4T1 cells via Western blotting following different treatments; (F) Changes in tumor volume among different groups of mice with 4T1 tumors. (Reprinted with permission from [28]. Copyright 2023, American Chemical Society.)"
Figure 5
(A) Schematic illustration of BTO nanoparticles coated with membranes that overexpress M-αPD-L1; (B) Assessment of ROS generation capabilities across various groups; (C) O2 production levels in different experimental groups; (D) Fluorescence microscopy images showing the release of CRT, HMGB1, and HSP70 following various treatments; (E) Changes in tumor volume in mice bearing B16F10 tumors after different treatment regimens; (F) Photographic representation of B16F10 tumors post-treatment. (Reprinted with permission from [29]. Copyright 2023, John Wiley and Sons.)"
Figure 6
(A) Schematic illustration of the synthesis of Met@BF nanohybrids and their enhanced immunochemotherapy effects for melanoma; (B) Release behavior of Fe ions from Met@BF nanohybrids at various pH levels; (C) H2O2 concentrations in different samples following ultrasound irradiation; (D) Confocal fluorescence images depicting CRT surface exposure and HMGB1 secretion in B16F10 cells after various treatments; (E) Tumor growth curves for C57BL/6 mice with B16F10 tumors subjected to different treatment protocols. (Reprinted with permission from [30]. Copyright 2024, American Chemical Society)"
| [1] | Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J. Clin 2022; 72:7-33. |
| [2] | Zhang K, Qi C, Cai K. Manganese-based tumor immunotherapy. Adv Mater 2023; 35:e2205409. |
| [3] | Xie X, Zhang J, Wang Y, Shi W, Tang R, Tang Q, et al. Nanomaterials augmented bioeffects of ultrasound in cancer immunotherapy. Materials Today Bio 2024; 24:100926. |
| [4] | Wang P, Sun S, Ma H, Sun S, Zhao D, Wang S, et al. Treating tumors with minimally invasive therapy: A review. Mat Sci Eng C 2020; 108:110198. |
| [5] |
Zhang L, Lin Z, Zeng L, Zhang F, Sun L, Sun S, et al. Ultrasound-induced biophysical effects in controlled drug delivery. Sci China Life Sci 2021; 65:896-908.
doi: 10.1007/s11427-021-1971-x pmid: 34453275 |
| [6] | Xu Y, Liang X, Bhattarai P, Sun Y, Zhou Y, Wang S, et al. Enhancing therapeutic efficacy of combined cancer phototherapy by ultrasound‐mediated in situ conversion of near‐Infrared Cyanine/Porphyrin microbubbles into nanoparticles. Adv Funct Mater 2017; 27:1704096. |
| [7] | Zhang J, Sun L, Jiang L, Xie X, Wang Y, Wu R, et al. Regulation of CTLs/Tregs via Highly Stable and Ultrasound‐Responsive Cerasomal Nano‐Modulators for Enhanced Colorectal Cancer Immunotherapy. Adv. Sci 2024; 11:2400485. |
| [8] | Lin X, Zhang X, Wang S, Liang X, Xu Y, Chen M, et al. Intraoperative identification and guidance of bbreast cancer microfoci using ultrasound and near-infrared fluorescence dual-modality imaging. ACS Appl Bio Mater 2019; 2:2252-2261. |
| [9] | Yang S, Wang Y, Liang X. Piezoelectric nanomaterials activated by ultrasound in disease treatment. Pharmaceutics 2023; 15:1338. |
| [10] | Wang X, Dai X, Chen Y. Sonopiezoelectric nanomedicine and materdicine. Small 2023; 19:2301693. |
| [11] | Sood A, Desseigne M, Dev A, Maurizi L, Kumar A, Millot N, et al. A comprehensive review on barium titanate nanoparticles as a persuasive piezoelectric material for biomedical applications: Prospects and challenges. Small 2022; 19:2206401. |
| [12] | Rooksby HP. Compounds of the structural type of calcium titanate. Nature 1945; 155:484-484. |
| [13] | Zhao Y, Huang T, Zhang X, Cui Y, Zhang L, Li L, et al. Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy. BMEMat 2023; 1:e12006. |
| [14] | Hong K-S, Xu H, Konishi H, Li X. Direct water splitting through vibrating piezoelectric microfibers in water. J Phys Chem Lett 2010; 1:997-1002. |
| [15] | Chen D, Wang L, Luo X, Fei C, Li D, Shan G, et al. Recent development and perspectives of optimization design methods for piezoelectric ultrasonic transducers. Micromachines 2021; 12:779. |
| [16] | Chen S, Zhu P, Mao L, Wu W, Lin H, Xu D, et al. Piezocatalytic medicine: An emerging frontier using piezoelectric materials for biomedical applications. Adv Mater 2023; 35:2208256. |
| [17] | Tu S, Guo Y, Zhang Y, Hu C, Zhang T, Ma T, et al. Piezocatalysis and piezo‐photocatalysis: Catalysts classification and modification strategy, reaction mechanism, and practical application. Adv Funct Mater 2020; 30:2005158. |
| [18] | Wang K, Han C, Li J, Qiu J, Sunarso J, Liu S. The Mechanism of piezocatalysis: Energy band theory or screening charge effect? Angew Chem Int Ed 2021; 61:e202110429. |
| [19] | Zhou X, Wu S, Li C, Yan F, Bai H, Shen B, et al. Piezophototronic effect in enhancing charge carrier separation and transfer in ZnO/BaTiO3 heterostructures for high-efficiency catalytic oxidation. Nano Energy 2019; 66:104127. |
| [20] | Ji J, Yang C, Shan Y, Sun M, Cui X, Xu L, et al. Research trends of piezoelectric nanomaterials in biomedical engineering. Adv Nanobiomed Res 2022; 3:2200088. |
| [21] | Zhu P, Chen Y, Shi J. Piezocatalytic tumor therapy by ultrasound-triggered and BaTiO3-mediated piezoelectricity. Adv Mater 2020; 32:2001976. |
| [22] |
Wang P, Tang Q, Zhang L, Xu M, Sun L, Sun S, et al. Ultrasmall barium titanate nanoparticles for highly efficient hypoxic tumor therapy via ultrasound triggered piezocatalysis and water splitting. ACS Nano 2021; 15:11326-11340.
doi: 10.1021/acsnano.1c00616 pmid: 34180675 |
| [23] | Xiang Z, Xu L, Shan Y, Cui X, Shi B, Xi Y, et al. Tumor microenvironment-responsive self-assembly of barium titanate nanoparticles with enhanced piezoelectric catalysis capabilities for efficient tumor therapy. Bioact 2024; 33:251-261. |
| [24] | Deng R, Zhou H, Qin Q, Ding L, Song X, Chang M, et al. Palladium‐catalyzed hydrogenation of black barium titanate for multienzyme‐piezoelectric synergetic tumor therapy. Adv Mater 2023; 36:2307568. |
| [25] | Zhao Y, Wang S, Ding Y, Zhang Z, Huang T, Zhang Y, et al. Piezotronic effect-augmented Cu2-xO-BaTiO3 sonosensitizers for multifunctional cancer dynamic therapy. ACS Nano 2022; 16:9304-9316. |
| [26] | Yue Z, Zhao Q, Wang S, Yao S, Wan X, Hu Q, et al. Manganese dioxide coated piezoelectric nanosonosensitizer for cancer therapy with tumor microenvironment remodeling and multienzyme‐like catalysis. Small Methods 2024:202400018. |
| [27] |
Wang Y, Tang Q, Wu R, Sun S, Zhang J, Chen J, et al. Ultrasound-triggered piezocatalysis for selectively controlled NO gas and chemodrug release to enhance drug penetration in pancreatic cancer. ACS Nano 2023; 17:3557-3573.
doi: 10.1021/acsnano.2c09948 pmid: 36775922 |
| [28] | Chen J, Tang Q, Wang Y, Xu M, Sun S, Zhang J, et al. Ultrasound-induced piezocatalysis triggered NO generation for enhanced hypoxic tumor therapy. ACS Appl Mater 2023; 15:15220-15234. |
| [29] | Tang Q, Sun S, Wang P, Sun L, Wang Y, Zhang L, et al. Genetically engineering cell membrane-coated BTO nanoparticles for MMP2-activated piezocatalysis-immunotherapy. Adv Mater 2023; 35:2300964. |
| [30] |
Wang Y, Tang Q, Wu R, Yang S, Geng Z, He P, et al. Metformin-mediated fast charge-reversal nanohybrid for deep penetration piezocatalysis-augmented chemodynamic immunotherapy of cancer. ACS Nano 2024; 18:6314-6332.
doi: 10.1021/acsnano.3c11174 pmid: 38345595 |
| [31] | Wang L, Zhang X, You Z, Yang Z, Guo M, Guo J, et al. A molybdenum disulfide nanozyme with charge‐enhanced activity for ultrasound‐mediated cascade‐catalytic tumor ferroptosis. Angew Chem Int Ed 2023; 62:e202217448. |
| [1] | Liu Taixia, Wang Hanxiang, Wang Dan, Zhang Yuke, Guo Yunyun, Liu Shuo, Zhang Minfeng, Nie Hongming, Shen Rui. The Role of Sonazoid-contrast-enhanced Ultrasound In Precision Diagnosis and Guidance for Radiofrequency Ablation Therapy of Hepatocellular Carcinoma: a Literature Review [J]. Advanced Ultrasound in Diagnosis and Therapy, 2026, 10(1): 20-28. |
| [2] | Fu Lijia, Li Na, Liao Ziling, Lin Yanping, Li Zhaojun, Li Fan. Advances in Breast Ultrasound Segmentation and Classification [J]. Advanced Ultrasound in Diagnosis and Therapy, 2026, 10(1): 29-41. |
| [3] | Li Na, Li Fan. Focused Ultrasound Combined with Microbubbles for Inducing Blood-Brain Barrier Opening: Cavitation Monitoring and Control [J]. Advanced Ultrasound in Diagnosis and Therapy, 2026, 10(1): 51-58. |
| [4] | Yin Yulian, Cheng Yifan, Zhou Liangmei, Zhong Yuanyuan, Wang Bing, Wu Jingjing, Ren Yajuan, Gao Dongwen, Chen Hongfeng, Ye Meina, Yin Haoqiang. From Non-Mass Stage to Complex Type: Ultrasonographic Assessment of Granulomatous Lobular Mastitis Across Six Clinical Stages [J]. Advanced Ultrasound in Diagnosis and Therapy, 2026, 10(1): 59-68. |
| [5] | Syahril Erlin, Abdullah Nusratuddin, Ilyas Muhammad, As’ad Suryani, Choridah Lina, Natzir Rosdiana, Kurniawan Liong Boy, Bahar Burhanuddin, Mappaware Nasrudin A., Mulyadi Farah Ekawati, Yacca Susdiaman Sudin. The Effects of Ajwa Dates Consumption (Phoenix dactylifera L), on Ovarian Follicular Features with Transvaginal Ultrasound in Perimenopausal Women [J]. Advanced Ultrasound in Diagnosis and Therapy, 2026, 10(1): 69-73. |
| [6] | Si Jiahao, Zhang Ye, Wang Shuaiyanga, Hao Liuwei, Duan Shaobo. Ultrasound-Guided Portal Vein Puncture for The Treatment of Hepatic Portal Venous Gas: A Case Report [J]. Advanced Ultrasound in Diagnosis and Therapy, 2026, 10(1): 74-78. |
| [7] | Guan Xin, Hu Xinyuan, Han Hong, Zhang Dezhi, Xu Huixiong. The Evolving Application of Ultrasound in the Precision Management of Small Hepatocellular Carcinoma [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 375-387. |
| [8] | Li Yanran, Cui Yuanjie, Wu Qingqing, Zhang Na. Current Applications of Artificial Intelligence in Obstetric Ultrasound [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 449-456. |
| [9] | Hou Wenfei, Chen Wanting, Liu Huazhen, Tang Jiajia, Yang Meng. Applications of Ultrasound Localization Microscopy in Abdominal Imaging [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 347-356. |
| [10] | Yu Xiao jie, Song Zheng lai, Chang Xue yong, Yu Jie, Liang Ping. Artificial Intelligence in Ultrasound Diagnosis of Liver Nodules: A Comprehensive Review of B-Mode and Contrast-enhanced Applications [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 326-346. |
| [11] | Zhong Xian, Xie Xiaoyan. Multimodal Ultrasound Radiomics in Liver Disease: Current Status and Future Directions [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 388-408. |
| [12] | Zhang Xiaoqian, Zhang Jingwen, Dong Yijie, Zhou Jianqiao. Research Progress and Clinical Translation of Photoacoustic–ultrasound Fusion Imaging in Breast Cancer Diagnosis and Therapy [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 467-482. |
| [13] | Jin Tong, Yu Xiaohu, Ai Zheng, Guo Hongcheng. Artificial Intelligence in Ultrasound Imaging: A Review of Progress from Machine Learning to Large Language Model [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 483-496. |
| [14] | Xiang Xi, Yang Yujia, Wang Liyun, Qiu Li. Advances and Applications in Dermatological Ultrasound [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 457-466. |
| [15] | Zheng Hairong, Meng Long, Li Fei, Niu Lili, Qiu Weibao, Ma Teng, Liu Chengbo, Zhu Xuefeng, Wan Liwen, Cai Feiyan. Advance in Ultrasound Super-resolution Imaging, Cell Manipulation and Inter-brain Communication [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 307-325. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
Share: WeChat
Copyright ©2018 Advanced Ultrasound in Diagnosis and Therapy
|
Advanced Ultrasound in Diagnosis and Therapy (AUDT) a>
is licensed under a Creative Commons Attribution 4.0 International License a>.
