Table 1

Current US LI-RADS algorithm from the American College of Radiology [6]."

Table 2

Current CEUS LI-RADS algorithm used from the American College of Radiology [6]."

Figure 1

(A) Sagittal image of a hepatic segment 8 isoechoic solid observation measuring 28 mm; (B) At 22 seconds, the lesion demonstrates peripheral globular enhancement during the arterial phase; (C and D) At 1 minute and 5 minutes post injection show no washout with continued peripheral globular enhancement."

Figure 2

(A) Sagittal and transverse images of a hepatic segment 3 hyperechoic solid observation measuring 27 mm; (B) This image is at 25 seconds, demonstrating peripheral globular enhancement during the arterial phase with areas of non-enhancement; (C and D) Images obtained at 1- and 4-minutes post-injection showing iso-enhancement with no washout."

Figure 3

(A) Sagittal image of a hepatic segment 6 solid isoechoic observation measuring 37 mm; (B) This image is at 23 seconds, demonstrating global iso-enhancement during arterial phase; (C and D) Images obtained at 2- and 6-minutes post-injection show an iso-enhanced observation with no washout."

Figure 4

(A) Sagittal and transverse images of a hepatic segment 5 hyperechoic solid observation measuring 20 mm; (B) This image is at 17 seconds, demonstrating global iso-enhancement during the arterial phase; (C-E) Images obtained at 1-, 3-, and 5-minutes post-injection show iso-enhancement with no washout."

Figure 5

(A) Sagittal and transverse images of a hepatic segment 8 solid hyperechoic observation measuring 11 mm; (B) This image is taken at 19 seconds, demonstrating global hypo-enhancement during arterial phase; (C and D) Images obtained at 4- and 6-minutes post-injection show no washout."

Figure 6

(A) Sagittal and transverse images of a hepatic segment 4 hypoechoic solid observation measuring 14 mm; (B) Image at 17 seconds, demonstrating global iso-enhancement during the arterial phase; (C and D) Images at 2- and 4-minutes post-injection show iso-enhancement with no washout."

Figure 7

(A) Sagittal and transverse images of a hepatic segment 6 solid hyperechoic observation measuring 19 mm; (B) At 22 seconds the lesion demonstrates global hyper-enhancement during the arterial phase; (C and D) Images obtained at 1- and 4-minutes post-injection show an iso-enhanced observation with no washout."

Figure 8

(A) Sagittal and transverse images of a hepatic segment 6 with mixed echogenicity solid observation measuring 18 mm; (B) At 12 seconds the lesion demonstrates global hyper-enhancement during the arterial phase; (C-E) Images obtained at 1-, 2-, and 5-minutes post-injection show iso-enhancement with no washout."

Figure 9

(A) Sagittal and transverse images of a hepatic segment 2 solid isoechoic with circumscribed margins measuring 33 mm; (B) At 8 seconds the lesion demonstrates global hyper-enhancement during the arterial phase; (C and D) Images obtained at 4- and 7-minutes post-injection show mild weak washout."

Figure 10

(A) Sagittal and transverse images of a hepatic segment 5 hypoechoic solid observation measuring 16 mm; (B) At 18 seconds the lesion demonstrates global hyper-enhancement during the arterial phase; (C-E) Images obtained at 1-, 2-, and 5-minutes post-injection show mild washout."

Figure 11

(A) Transverse image of a hepatic segment 4 solid isoechoic with irregular margins; (B) This image is at 24 seconds, demonstrating global hyper-enhancement during the arterial phase; (C and D) Images obtained at 3- and 4-minutes post-injection, showing mild washout."

Figure 12

(A) Sagittal and transverse images of a hepatic segment 8 infiltrative hypoechoic solid observation measuring 17 mm; (B) This image is at 12 seconds, demonstrating global hyper-enhancement during the arterial phase; (C-E) Images obtained at 2-, 3-, and 5-minutes post-injection, demonstrating mild washout."

Figure 13

(A) Sagittal image of a hepatic segment 7 solid hypoechoic observation measuring 35 mm; (B) At 16 seconds the lesion demonstrates rim enhancement during the arterial phase; (C and D) Images obtained at 3- and 5-minutes post-injection, showing mild washout."

Figure 14

(A) Sagittal and transverse images of a hepatic segment 8 mixed echogenicity solid observation measuring 32 mm; (B) This image is at 25 seconds. The image demonstrates global hyper-enhancement during arterial phase; (C) This image is at 50 seconds post-injection, showing marked washout; (D and E) Images obtained at 1- and 2-minutes post-injection continuously demonstrating marked washout."