The Diagnostic Value of Real-time Shear Wave Ultrasound Elastography in the Differentiation of Hepatic Hemangioma and Hepatocellular Carcinoma

doi:10.37015/AUDT.2023.230057

Abstract

Abstract:

Objective: To explore the diagnostic value of real-time shear wave elastography (SWE) in hepatic hemangioma (ANGI) and hepatocellular carcinoma (HCC).

Methods: A total of 88 patients diagnosed with angiosarcoma (ANGI) or hepatocellular carcinoma (HCC) in our department from February 2019 to February 2020 were included in this study. These patients were assigned to two groups based on pathological diagnosis: the ANGI group (n = 42) and the HCC group (n = 46). All patients underwent SWE examination, and the clinical efficacy was analyzed by comparing the average value of Young's modulus of the two groups and plotting the receiver operator characteristic (ROC) curve.

Results: There was no significant difference in lesion diameter between ANGI and HCC patients (P > 0.05). The ANGI group exhibited a significantly higher average Young's modulus for both the lesions and the adjacent liver tissues compared to the HCC group (P < 0.001); The area under the curve (AUC) of the average value of Young’s modulus of the lesion to ANGI and HCC was 0.875 (95% CI = 0.795-0.955).

Conclusion: SWE demonstrates high diagnostic accuracy in distinguishing ANGI from HCC, providing valuable clinical evidence for differentiating between the two diseases.

Key words: Shear wave elastography; Hepatic hemangioma; Hepatocellular carcinoma; Diagnosis

Yue Tian, MB, Yanan Zhao, MD, Yiran Huang, MB. The Diagnostic Value of Real-time Shear Wave Ultrasound Elastography in the Differentiation of Hepatic Hemangioma and Hepatocellular Carcinoma. Advanced Ultrasound in Diagnosis and Therapy, 2024, 8(3): 124-129.

Figures/Tables 6

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Items	ANGI group (n = 42)	HCC group (n = 46)	χ²/t	P value
Gender			0.070	0.792
Male	24 (57.14%)	25 (54.35%)
Female	18 (42.86%)	21 (45.65%)
Age (years)	48.72 ± 5.72	48.81 ± 5.69	0.074	0.941
BMI (kg/m²)	21.14 ± 1.35	21.35 ± 1.46	0.699	0.487
Mean course of disease (months)	11.26 ± 3.26	11.31 ± 3.25	0.072	0.943
Marriage			0.369	0.544
Unmarried	3 (7.14%)	5 (10.87%)
Married	35 (83.33%)	36 (78.26%)
Divorced	4 (9.52%)	5 (10.87%)
Place of residence			0.002	0.969
Urban	19 (45.24%)	21 (45.65%)
Rural	23 (54.76%)	25 (54.35%)
Education level			0.390	0.532
Junior college and above	12 (28.57%)	16 (34.78%)
High school	19 (45.24%)	17 (36.96%)
Middle school and below	11 (26.19%)	13 (28.26%)

Detection result variable	AUC	Standard error^a	Asymptotic Sig.^b	Asymptotic 95% confidence interval
Detection result variable	AUC	Standard error^a	Asymptotic Sig.^b	Lower limit	Upper limite
Average value of Young’s modulus	0.875	0.041	< 0.001	0.795	0.955