Explainable Artificial Intelligence in Echocardiography

doi:10.26599/AUDT.2025.250089

Advanced Ultrasound in Diagnosis and Therapy ›› 2025, Vol. 9 ›› Issue (4): 409-425.doi: 10.26599/AUDT.2025.250089

收稿日期:2025-09-20 修回日期:2025-10-02 接受日期:2025-10-13 出版日期:2025-12-30 发布日期:2025-11-06

Explainable Artificial Intelligence in Echocardiography

Hu Xuelin^a^,^b^,^c^,¹, Zhu Ye^a^,^b^,^c^,¹, Zhang Zisang^a^,^b^,^c, Quan Yuanting^a^,^b^,^c, Chen Wenwen^a^,^b^,^c, Chen Leichong^a^,^b^,^c, Xu Guangyu^a^,^b^,^c, Qin Luning^a^,^b^,^c, Xie Mingxing^a^,^b^,^c^,^*(), Zhang Li^a^,^b^,^c^,^*()

^aDepartment of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
^bClinical Research Center for Medical Imaging in Hubei Province
^cHubei Province Key Laboratory of Molecular Imaging

Received:2025-09-20 Revised:2025-10-02 Accepted:2025-10-13 Online:2025-12-30 Published:2025-11-06
Contact: Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China (Mingxing Xie, Li Zhang).e-mail: xiemx@hust.edu.cn (MX X);zli429@hust.edu.cn(L Z)
About author:¹Xuelin Hu and Ye Zhu contributed equally to this work.

摘要/Abstract

Abstract:

Recent advancements in artificial intelligence (AI) have generated novel opportunities and challenges in ultrasound imaging. Deep learning algorithms exhibit significant potential in analyzing echocardiographic images, encompassing tasks such as view classification, quantification of cardiac function, and the diagnosis and risk assessment of cardiac diseases. The “black box” nature of AI models limits their clinical applications. Adopting explainable artificial intelligence (XAI) methods is crucial for improving the transparency and understanding of model predictions. This paper reviews the progress of AI applications in echocardiography, with a particular emphasis on XAI as a technical solution to enhance the transparency of model decision-making and its benefits compared to traditional AI models. This review outlines recent advancements in XAI applications for echocardiography and their clinical implications.

Key words: Explainable artificial intelligence, Echocardiography, Deep learning

. [J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 409-425.

Hu Xuelin, Zhu Ye, Zhang Zisang, Quan Yuanting, Chen Wenwen, Chen Leichong, Xu Guangyu, Qin Luning, Xie Mingxing, Zhang Li. Explainable Artificial Intelligence in Echocardiography[J]. Advanced Ultrasound in Diagnosis and Therapy, 2025, 9(4): 409-425.

图/表 12

Name	Purpose	Data source	Data	Annotator	Links
LVEF, left ventricular ejection fraction; A4C, apical four chamber; A2C, apical two chamber; PLAX, parasternal long-axis; LA, left atrium; A3C, apical three chamber; A5C, apical five chamber; PSAX, parasternal short-axis; RWMA, regional wall motion abnormality; PH, pulmonary hypertension; ASD, atrial septal defect; RVEF, right ventricular ejection fraction; 3DE, three dimension echocardiography
CAMUS [4,43]	LVEF measurement	Single-center, France	500 patients; A4C, A2C sequences	Clinicians	https://humanheart-project.creatis.insa-lyon.fr/database/#collection/6373703d73e9f0047faa1bc8/folder/64b5a9b473e9f00492ce9036
EchoNet-Dynamic [5]	LV function and structure assessment	Multi-center, America	10,030 A4C videos	Clinicians	https://echonet.github.io/dynamic/
EchoNet-LVH [70]	Ventricular hypertrophy quantification and cause prediction	Multi-center, America	23,745 patients; 12,000 PLAX videos	Clinicians	https://echonet.github.io/lvh/
HMC-QU [71]	Myocardial infarction detection and left ventricle wall segmentation	Single-center, Qatar	160 A4C videos	Clinicians	https://www.kaggle.com/datasets/aysendegerli/hmcqu-dataset
SyntheticDataQA2DSTE [72]	Speckle tracking algorithm assessment	Multi-center	7 different systems; 105 synthetic sequences	Simulation data	http://bit.ly/SyntheticDataQA2-DSTE
Unity Imaging Collaborative [70]	LV function assessment	Multi-center, Britain	21,866 A2C, A3C, A4C, A5C, PLAX images	Clinicians	https://data.unityimaging.net/
TMED-1 [73]	View classification and heart disease severity diagnosis	Single-center, Qatar	2,773 patients; 318,481 PLAX, PSAX, or other images	Clinicians	https://tmed.cs.tufts.edu/tmed_v1.html
TMED-2 [74]	View classification and heart disease severity diagnosis	Single-center, Qatar	6,567 patients; 442,636 PLAX, PSAX, A2C, A4C, or other images	Clinicians	https://tmed.cs.tufts.edu/tmed_v2.html
Seg RWMA [75]	Recognition of RWMA	Single-center, China	198 patients; 1,782 A4C, A3C, A2C videos；9,881 A4C, A4C, A3C, A2C images	Clinicians	https://www.kaggle.com/datasets/xiaoweixumedicalai/regional-wall-motion-abnormality-echo
Cardiac UDC [76]	Heart structure segmentation	Single-center, China	516 patients; 992 PLAX, PSAX, A4C videos	Clinicians	https://www.kaggle.com/datasets/xiaoweixumedicalai/cardiacudc-dataset
Abnorm Cardiac Echo Videos [77]	Heart disease diagnosis	Single-center, China	507 PH, 243 ASD; 750 A4C videos	Clinicians	https://www.kaggle.com/datasets/xiaoweixumedicalai/abnormcardiacechovideos
Echocardiogram Matched Subset [78]	Recognition of RWMA	Single center, America	4,579 patients; >500,000 images	Clinicians	https://physionet.org/content/mimic-iv-echo/0.1/
RVENet [12,79]	RVEF measurement	Single-center, Hungary	859 patients; 3,583 A4C videos	Clinicians	https://www.cardiacatlas.org/
MITEA [80]	LV function assessment	Single-center, New Zealand	143 patients; 536 3DE images	Clinicians	https://www.cardiacatlas.org/

Study	Objective	Data*	Model	Performance	View	XAI
*, The volume of data corresponds to the research phase. LVDF, left ventricular diastolic function; HFpEF, heart failure with preserved ejection fraction; AUC, area under curve; Corr, correlation; MAE, masked autoencoders; R², R-Square; LV, left ventricle F1: F1 score; ML, machine learning; LAV, left atrial volume; RWMA, regional wall motion abnormalities; APs, active polynomials; SVM, support vector machine; DT, decision tree; RF, random forest; KNN, k-nearest neighbor; XGB, eXtreme Gradient Boosting; PH, pulmonary hypertension; RVEF, right ventricular ejection fraction; RVOT, right ventricular outflow tract; AO, aorta; RV, right ventricle; NLP, natural language processing
Xu et al.(2023) [86]	View classification; Cardiac function -LVDF	1,304 studies (view); 2,150 studies (LVDF)	CNN	Acc. 0.92	5 views	Grad-CAM
Akerman Ashley et al.(2023) [87]	Cardiac function - HFpEF	6756 cases	CNN	AUC 0.97	A4C	Grad-CAM
Dai et al.(2023) [88]	Cardiac function-LVEF	EchoNet-Dynamic, CAMUS	ML	MAE 4.17	A4C	attention heatmap
Mokhtari et al.(2022) [89]	Cardiac function-LVEF	EchoNet-Dynamic	EchoGNN	F1 0.78	A2C, A4C	learned weights on the echo-graph, average frame distance
Zhang et al.(2024) [90]	Cardiac function-LVEF	Echonet Dynamic, HMC-QU, CAMUS	DL	Acc. 0.94	A2C, A3C, A4C	t-SNE, Grad-CAM
Duffy et al.(2021) [32]	Cardiac function-LV volume	EchoNet-Dynamic	CNN	Acc. 0.93	A4C	Depth map
Barzegar et al.(2021) [34]	Cardiac function-LAV	621 videos	CNN	Acc. 0.94	A4C	feature map
Christensen et al.(2024) [10]	Cardiac function-LVEF	1,032,975 videos	EchoCLIP	AUC 0.86	A4C	PromptCAM,
Sanjeevi et al.(2023) [35]	RWMA	HMC-QU	Echo-Cardio 3D Net	AUC 0.82	A4C	Grad-CAM
Huang et al.(2020) [28]	RWMA	10,638 echocardiograms	CNN	AUR 0.91	5 views	feature map
Gomez et al.(2025) [91]	RWMA	CAMUS,HMC-QU	U-Net	Sen. 1.00	A2C, A3C, A4C	SHAP
Ragnarsdottir et al.(2024) [41]	Cardiac function -PH	1,311 videos	DL	Acc. 0.92	A4C, PSAX, PLAX	Grad-CAM
Tokodi et al.(2023) [12]	Cardiac function -RVEF	5,076 videos.	CNN	Acc. 0.78	A4C	occlusion
Hirata et al.(2024) [43]	Cardiac function -PH	885 patients	logistic regression, SVM, RF, XGB	Acc. 0.59	/	SHAP
Zhao et al.(2022) [92]	Cardiac function -RVOT, AO	177 videos, CAMUS	DL	Acc. 0.99	PSAX, A4C	feature map
Anand et al.(2024) [93]	Cardiac function -PH	7,853 patients	XGB	Acc. 0.82	/	SHAP
Hagberg et al.(2022) [40]	Cardiac function-RV	12,684 studies	DL, NLP	Acc. 0.92	A4C	Saliency map
Sun et al.(2024) [42]	Cardiac function-PH	3,912 subjects	chamber attention network	Acc.0.83	A4C, PLAX	t-SNE, Grad-CAM

Study	Diagnosis	Data*	Model	Performance	View	XAI
*, The volume of data corresponds to the research phase. HF, heart failure; CM, cardiomyopathy; AOSAX, short-axis view of the aortic valve; CASA, coronary artery short axis
Cikes et al.(2019) [49]	HF	1,106 patients	ML	a classification of a phenotypically heterogeneous HF cohort	A2C, A4C	intrinsically interpretable model
Shad et al.(2021) [50]	HF	723 patients	CNN	AUC 0.73	A4C	Grad-CAM
Ouyang et al.(2020) [5]	CM	10,030 videos	EchoNet-Dynamic	AUC 0.97	A4C	PromptCAM
Morita et al.(2021) [94]	CM	45 patients	CNN	AUC 0.86	6 views	Grad-CAM
Hwang et al.(2022) [56]	CM	930 subjects	CNN	Acc. 0.92	5 views	CAM
Liu et al.(2023) [95]	CM	1,807 videos	DL	AUC: ASD 0.99, DCM 0.98, HCM 0.99, prior MI 0.98, Normal 0.98	A4C	CAM
Chao et al.(2024) [57]	CM	381 patients	CNN	AUC 0.97	A4C	Grad-CAM
H et al.(2023 Dec) [96]	CM	91 studies	KNN, LR, MLP, RF, SVM, XGB	Acc. 0.73	A4C	feature map
Peng et al.(2024) [97]	CM	13,575 images	DL	Acc. 0.90	5 views	t-SNE, Grad-CAM
Vafaeezadeh et al.(2022) [98]	Valvular Disease	1,773 subjects	eight CNNs	Acc. 0.80	A4C, PLAX	Grad-CAM
Cheng et al.(2022) [67]	Valvular Disease	3,554 patients	CNN	Acc. 0.86	A4C	t-SNE, Deep LIME
Vafaeezadeh et al.(2023) [55]	Valvular Disease	1,773 subjects	CNN	Acc. 0.71	PLAX	Grad-CAM
Holste et al.(2023) [14]	Valvular Disease	5,257 studies	CNN	AUC 0.98	PLAX	Grad-CAM
Tang et al.(2024) [53]	Valvular Disease	2,31 patients	DL	Acc. 0.82	AOSAX	Grad-CAM
Gu et al.(2025) [52]	Valvular Disease	2572 studies	ProtoASNet	Acc.0.80	PLAX,PSAX	PCA, t-SNE, UMAP
Wang et al.(2021) [15]	Other	1,308 subjects	CNN	Acc. 0.95(CHD), Acc. 0.92(VSD or ASD)	5 views	adaptive soft attention scheme, occlusion analysis, relative confidence heat map
Zaman et al.(2021) [59]	Other	17,280 images	CNN, RNN	Acc. 0.80	A4C	Grad-CAM
Nurmaini et al.(2022) [99]	Other	76 pregnant women	4 CNNs	Acc. 1.0	4CV fetal	Grad-CAM, Guided-BP
Lee et al.(2022) [61]	Other	203 patients	six deep learning networks	Acc. 0.78	CASA	CAM
Zaman et al.(2024) [60]	Other	300 patients	CNN	improve the diagnostic Acc. in 70% of ‘difficult’ TTS cases	A4C	Grad-CAM
Jina et al.(2023) [100]	Other	34,368 images	ConvNeXt-V2	Acc. 0.86	4 views	feature map
Lee et al.(2025) [101]	Other	203 patients	MLRANet	Sen. 0.93	PSAX	t-SNE, UMAP, attention mechanism

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Type	Criteria	Rationale
Inclusion	XAI in echocardiography	XAI can be applied to many different applications. Still, the focus of our review is on echocardiography, since this area is one of the most critical applications of AI and XAI.
	The AI model is built based on human clinical data	In this review, we focus on predictive modeling using human clinical data.
	They studied from 2018 to 2025	Since 2018, the emergence of XAI tools like SHAP and Grad-CAM has helped solve the black box problem.
	The study focuses on XAI, so a relevant term is used in the title and/or abstract.	The goal of the study is on XAI, and the relevant terms include: explainable, explainability, interpretable, interpretability, understandable, understandability, comprehensible, comprehensibility, intelligible, machine learning, artificial intelligence, prediction model, predictive model, deep learning, AI, neural network.
Exclusion	Details of the paper are not available.	Abstract papers, or the papers that could not be accessed through the university library or the interlibrary loan, and system demonstrations are not included.
	Unpublished	We excluded papers uploaded on arXiv or other archiving systems not published in a peer-reviewed venue.
	Opinion or other review papers	This review is not a review of reviews, and opinion papers do not fulfill the requirement of delivering an XAI method.
	Duplicated	Usually, querying multiple databases returns similar papers. Thus, we removed the duplicates.

Term	Concept	Key point	Common method
Explainability	After-the-fact explanations	External tools	SHAP, LIME, Grad-CAM, etc.
Interpretability	Built-in understandability	Model simplicity	Linear models, decision trees
Transparency	System openness	Data/code visibility	Share data, algorithms
Trustworthiness	Overall reliability	Ethics/safety compliance	Fairness checks, validation
Understandable	User-friendly presentation	Clear communication	Visuals, simplified language techniques

XAI technique	Input datatype	Visual representations	Classification framework
XAI technique	Input datatype	Visual representations	phase	scope	model dependency
CAM, class activation mapping; SHAP, shapley additive explanations; LIME, local interpretable model-agnostic explanations
CAM/Grad-CAM	Image	Saliency map	post-hoc	Local	Model-agnostic
SHAP/Deep SHAP	Tabular/Text	Bar chart	post-hoc	Local/Global	Model-agnostic
Trainable attention	Image	attention map	post-hoc	Local	Model-specific
LIME/Deep LIME	Image/Text	Feature weights map	post-hoc	Local	Model-agnostic
Occlusion sensitivity	Image	/	post-hoc	Local	Model-agnostic

Study	Objective	Data*	Model	Performance	View	XAI
*, The volume of data corresponds to the research phase. QA, quality assessment; LVH, left ventricular hypertrophy; CNN, convolutional neural networks; Acc, accuracy; DL, deep learning; GCN, graph convolutional networks; RNN, recurrent neural networks; TaNet, trilateral attention network; Guided-BP, guided backpropagation
Gao et al.(2017) [7]	View classification	432 images	CNN	Acc. 0.92	8 views	the optical flow image
Gearhart et al.(2022) [81]	View classification	12,067 images	CNN	Acc. 0.90	6 views	UMAP
Madani et al.(2018) [8]	View classification, LVH classification	267 studies	CNN	Acc. 0.94	15 views	Generated sampled images
Huang et al.(2022) [82]	View classification	26,465 images	CNN	Acc. 0.98	/	deconvolution
Madani et al.(2018) [9]	View classification	267 studies	DL	Acc. 0.93	15 views	t-SNE, Guided-BP, occlusion
Thomas et al.(2023) [83]	View classification	4,258 synthetic images	GCN	Acc. 0.97	4 views	GCN explainer
Howard et al.(2019) [84]	View classification	9,098 videos	CNN, Two-Stream networks	Acc. 0.96	14 views	Saliency map
Charton et al.(2023) [26]	View classification	8,292 videos	RNN	Acc. 0.97	8 views	decision tree
Zhang et al.(2018) [24]	View classification, Cardiac function, diagnose	4035 echocardiograms	CNN	Acc. 0.96	23 views	t-SNE,
Labs et al.(2023) [85]	QA	11,262 patients	DL	Acc. 0.97	A4C, PLAX	feature map
Zamzmi et al.(2022) [11]	View classification, QA, Cardiac function	EchoNet-Dynamic, NIH dataset	TaNet	Acc. 0.97	5 views	ablation
Hsu et al.(2025) [29]	QA	514 videos	ConvNeXt	Acc. 0.89	A4C	Grad-CAM

Study	Objective	Data*	Model	Performance	View	XAI
*, The volume of data corresponds to the research phase. BNP, brain natriuretic peptide; BUN, blood urea nitrogen; CCS, chronic coronary syndromes; HCM, hypertrophic cardiomyopathy; LASSO, least absolute shrinkage and selection operator
Ulloa Cerna et al.(2021) [16]	predictions of one-year all-cause mortality	812,278 videos	CNN	improved the sensitivity by 13%	PLAX, A4C	occlusion
Valsaraj et al.(2023) [17]	identifying patients at high-risk of all-cause mortality	7,080 videos	CNN	AUC 0.92	/	Grad-CAM, SHAP
Molenaar et al.(2024) [64]	predict all-cause 5-year mortality in patients with CCS	1,253 patients	XGB	AUC 0.79	/	SHAP
Rhee et al.(2024) [102]	discriminate major cardiovascular events in patients with HCM	2,111 patients	Logistic, RF, SVM	AUC 0.80	/	SHAP
Dutta et al.(2020) [103]	classify coronary heart disease	the NHANES	CNN	Acc. 0.79	/	LASSO, t-SNE
Wang et al.(2021) [62]	prediction of 3-year all-cause mortality in patients with heart failure caused by coronary heart disease	5,188 patients	XGB	hazard ratio 10.35	/	SHAP
Petmezas et al.(2025) [104]	heart failure mortality prediction	233 patients	Extra-Trees	AUC 0.79	/	SHAP

Explainable Artificial Intelligence in Echocardiography

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