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Advanced Ultrasound in Diagnosis and Therapy ›› 2026, Vol. 10 ›› Issue (1): 20-28.doi: 10.26599/AUDT.2026.250084

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  • 收稿日期:2025-08-05 修回日期:2025-10-19 接受日期:2025-11-21 出版日期:2026-03-31 发布日期:2026-03-30

The Role of Sonazoid-contrast-enhanced Ultrasound In Precision Diagnosis and Guidance for Radiofrequency Ablation Therapy of Hepatocellular Carcinoma: a Literature Review

Liu Taixiaa, Wang Hanxianga, Wang Dana, Zhang Yukea, Guo Yunyuna, Liu Shuoa, Zhang Minfengb, Nie Hongmingc,*(), Shen Ruia,*()   

  1. aDepartment of Ultrasound, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    bDepartment of Hepatobiliary Surgery, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    cDepartment of Liver Disease, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • Received:2025-08-05 Revised:2025-10-19 Accepted:2025-11-21 Online:2026-03-31 Published:2026-03-30
  • Contact: Department of Liver Disease, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China (Hongming Nie), e-mail: beining0630@126.com(HM N); Department of Ultrasound, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China (Rui Shen), e-mail: shenrui@shutcm.edu.cn(R S)

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Abstract:

Hepatocellular carcinoma (HCC), constituting 75-85% of primary liver cancer cases, ranks as the third leading cause of global cancer-related mortality. The early diagnosis of HCC is critical for determining optimal clinical therapeutic strategies. Radiofrequency ablation (RFA) has emerged as a preferred for managing early-stage HCC cases, primarily due to its less invasive nature, simplicity and safety. Advanced imaging for pre-operative evaluation of HCC has been increasingly used. Contrast-enhanced ultrasound (CEUS) has improved the clinical application of ultrasound (US) in HCC. It also provide more accurate informations for guiding RFA procedures. In the future, CEUS, through its convergence with emerging artificial intelligence (AI)-driven technologies, will play an even greater role in HCC management. This systematic review evaluates the utility of Sonazoid-enhanced contrast ultrasound (Sonazoid-CEUS), particularly its unique Kupffer phase imaging, in improving HCC diagnostic and optimizing RFA precision via real-time monitoring capabilities and prolonged imaging windows (up to 60 minutes).

Key words: Hepatocellular carcinoma, Kupffer cell, Sonazoid-enhanced contrast ultrasound, Radiofrequency ablation

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CharacteristicsSonazoidSonoVue
GasPerfluorobutaneSulfur hexafluoride
Diameter2 um2.5 um
ShellSodium hydrolecithinylserineDistearoyl hosphatidylcholine
CharacteristicTranspulmonary circulation blood vessel + organ specific imagingTranspulmonary circulation angiography

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